Present in all eukaryotic cells, the endoplasmic reticulum (ER) is an extensive network of membranes that folds, modifies, and transports proteins, and manufactures lipids. This key organelle is the focus of a new book, The Endoplasmic Reticulum.
“The endoplasmic reticulum is one of the most intriguing and fascinating organelles,” write the editors, Susan Ferro-Novick, Tom Rapoport, and Randy Schekman. “This book attempts to capture in a single volume our current knowledge of this organelle and highlights many unresolved questions.”
Contributors examine how proteins translocate across the ER membrane, the folding and modification processes that occur inside the ER lumen, and how the proteins are packaged into vesicles and transported to the Golgi. They also review quality-control mechanisms that are employed by the ER to detect and eliminate misfolded or unassembled proteins. Lipid synthesis and transport are also discussed.
The Endoplasmic Reticulum is an indispensable reference for cell biologists interested in understanding the numerous functions of the ER. For more details on the book, click here.