Protein Synthesis and Translational Control“Situated at the nexus between nucleic acids and proteins, the importance of translational control, now appreciated for its role in establishing the cell’s proteome, is comparable to that of transcriptional control,” write John Hershey, Nahum Sonenberg, and Michael Mathews, editors of our recently released book Protein Synthesis and Translational Control. “It is especially important in defining the proteome, maintaining homeostasis, and controlling cell proliferation, growth, and development.”

The book covers our current understanding of all aspects of protein synthesis and its regulation. Contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high-resolution structures of the translational machinery where this takes place.  They also review the targets of translational control (e.g., initiation factors and mRNAs) and how signaling pathways modulate this machinery.  The book will be useful to cell and molecular biologists, as well as cancer biologists and others who study human diseases associated with translation dysfunction. For more information, click here.