“The shaking palsy,” as it was first described by James Parkinson in 1817, is a disabling neurodegenerative disorder common among the elderly. Parkinson’s Disease, a new book edited by Serge Przedborski, provides a current review of the disease, from its neuropathological and clinical bases to diagnostic challenges and therapeutic interventions.

The book is “designed specifically to bridge the clinical and basic science aspects of Parkinson’s disease under one cover,” writes Przedborski. It will be useful for neurobiologists, cell biologists, and pathologists pursuing the biological basis of Parkinson’s disease, as well as scientists and clinicians interested in its diagnosis and treatment.

Contributors discuss the mutations in genes encoding proteins such as α-synuclein, parkin, and LRRK2 that cause Parkinson’s disease; the roles of mitochondria, autophagy, protein quality control, and programmed cell death in disease progression; and the chemistry and anatomy of the basal ganglia that are affected. The use of functional neuroimaging and experimental models to probe the neurobiology of Parkinson’s disease are also described. For more information, click here.