The growth and survival of tumors depends on angiogenesis, the process by which new blood vessels are formed from preexisting vessels.  Similar processes are required for proper embryonic development, patterning of the vascular system, and wound healing.  Our new book Angiogenesis: Biology and Pathology reviews the mechanisms of angiogenesis that operate in normal and disease states.

In 30 chapters, contributors review the biology of endothelial cells, describing the specific roles of tip and stalk cells in vessel sprouting and formation. They discuss key angiogenic regulators (e.g., VEGF), as well as antiangiogenic agents including microRNAs, thrombospondins, and semaphorins.  Therapeutic approaches that target pathological angiogenesis, such as the ongoing clinical trials of anti-VEGF drugs, are also covered.

“It is hoped that the vast amount of basic knowledge about angiogenesis that has been acquired over the last four decades and reported in this volume will result in improved therapies for angiogenesis-dependent disease,” write the editors, Michael Klagsbrun and Patricia D’Amore.

Angiogenesis: Biology and Pathology is a vital reference for developmental and cancer biologists, as well as anyone seeking to understand the biology and pathology of the vascular system.  For more details on the book, click here.