Understanding the complex changes that occur during Alzheimer disease—including the accumulation of amyloid plaques and neurofibrillary tangles in the brain—is critical for the development of successful therapeutic approaches.  Our newest book, The Biology of Alzheimer Disease, provides a current and comprehensive review of the biological basis of Alzheimer disease (AD).

The editors, Dennis Selkoe, Eckhard Mandelkow, and David Holtzman, chose leading researchers in Alzheimer biology to contribute chapters on topics in which they have deep expertise. The 25 chapters include contributions covering all aspects of Alzheimer disease, from our current molecular understanding of it to therapeutic agents that could be used to treat and prevent it.

Additionally, the first and last chapters provide the editors’ perspectives on the disease, its challenges and prospects for developing effective treatments. “[We] have tried to step back from the wealth of details and convey a sense of what has motivated the global quest to understand the biology of AD, how sometimes competing concepts and lines of inquiry have proceeded, and, most importantly, where we believe this scientifically rich and therapeutically promising field is headed,” they write.

The book is a vital reference for neurobiologists, cell biologists, pathologists, and other scientists pursuing the biological basis of Alzheimer disease, as well as investigators, clinicians, and students interested in its pathogenesis, treatment, and prevention.  For more details, click here.